The median intervention duration was 12 weeks, and self-report was the most commonly used method to assess medication adherence. Results Sixteen randomized clinical trials were included, with 5 of 16 using personalization, 8 of 16 using 2-way communication, and 8 of 16 using a daily text message frequency. Risk of bias and study quality were assessed as per Cochrane guidelines. Main Outcomes and Measures Odds ratios and pooled data were calculated using random-effects models. Study Selection Randomized clinical trials evaluating a mobile telephone text message intervention to promote medication adherence in adults with chronic disease.ĭata Extraction Two authors independently extracted information on study characteristics, text message characteristics, and outcome measures as per the predefined protocol. Objectives To conduct a meta-analysis of randomized clinical trials to assess the effect of mobile telephone text messaging on medication adherence in chronic disease.ĭata Sources MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL (from database inception to January 15, 2015), as well as reference lists of the articles identified. Mobile telephone text messaging may be a scalable means to support medication adherence. Traditional interventions to improve adherence are complex and not widely effective. Importance Adherence to long-term therapies in chronic disease is poor. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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